Ms Le Pen said her decision had been made out of the "profound conviction" that the president must bring together all of the French people.
"So, this evening, I am no longer the president of the National Front. I am the candidate for the French presidency," she said.
The BBC's Hugh Schofield in Paris says this is a symbolic act intended to show her concerns are for the country as a whole and not for her party, and that she is reaching out for the voters of candidates defeated in the first round, particularly those of the Republicans' François Fillon.
Meanwhile, also on Monday, Mr Fillon told party leaders that he "no longer had the legitimacy" to take the party into legislative elections that will follow next month's presidential run-off.
He said he would become "an ordinary activist like any other".
62%
Emmanuel Macron
38%
Marine Le Pen
304050607080MarApr7 May: Election23 Apr: First vote*62%38%
Last updated 25 April, 2017
*Polling results up to this date show how people said they would vote on 7 May, if Macron and Le Pen reached the second round
The polling average line looks at the five most recent national polls and takes the median value, ie, the value between the two figures that are higher and two figures that are lower.
Ms Le Pen took over the FN leadership from her father, Jean-Marie Le Pen, in January 2011. 'Hollande's baby': BBC's Hugh Schofield on the Le Pen interview
Marine Le Pen has gone straight on to the attack. If the polls are to be believed, she has a lot of ground to make up - and she wants to hit Emmanuel Macron hard and early.
The ideological battle lines are clear. From now until 7 May, she will portray her rival as representing a kind of anti-France. Nothing in his programme, she said in her TV interview, suggested he had one iota of love for France; she, by contrast, is the patriot.
The other line of attack is to play up his past associations with President François Hollande. Mr Macron is "Hollande's baby", she said in the interview. This is clever politics, because the same argument was used before the first round by François Fillon's Republicans, whose votes she now needs.
If Mr Macron was unacceptable then, she is saying, then he is still unacceptable now. So vote for me.
She won 7.6 million votes on Sunday - the strongest ever result for a FN candidate, and 2.8 million more than her father won in 2002.
Her party wants to slash immigration, clamp down on trade, and overturn France's relationship with Europe.
Her campaign has called for: Negotiation with Brussels on a new EU, followed by a referendum "Automatic" expulsion of illegal immigrants and legal immigration cut to 10,000 per year following an immediate total moratorium "Extremist" mosques closed and priority to French nationals in social housing Retirement age fixed at 60 and 35-hour week assured Is Marine Le Pen far-right? The French have voted against the system: Voters react Online calls for boycott
Mr Macron, a former economy minister, is widely expected to win the run-off vote on 7 May.
On Monday, he won the backing of President Hollande, to go with that of two defeated candidates.
President Hollande said the far right would threaten the break-up of Europe, "profoundly divide France" and "faced with such a risk, I will vote for Emmanuel Macron".
He said his former economy minister would "defend the values which will bring French people together".
Mr Fillon and Socialist Benoît Hamon both urged their supporters to vote for Mr Macron.
Mr Macron, 39, has never stood for election before, and if he wins would become France's youngest-ever president.
His campaign promises include: Cut 120,000 public sector jobs and bring down the budget deficit A €50bn (£43bn; $53bn) public investment plan to cover job-training and shift to renewable energy Slash corporation tax from 33% to 25% and let companies renegotiate 35-hour week. Unify the pension system Bolster EU ties and the eurozone, higher tariffs to protect European industry, common border force
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